University of Limerick, Ireland research coul

Researchers at University of Limerick in Ireland have developed a new modeling approach to pharmaceutical manufacturing that could reduce the time required to bring medicines to market.

Professor Gavin Walker at University of Limerick’s Bernal Institute has had a world’s first paper published in applying molecular engineering methodologies to continuous pharmaceutical manufacturing.

The paper addresses an important public health issue of reducing the time required to bring new medicines to market for the benefit of patients and society.

The pharmaceutical industry has recently been increasing research in continuous manufacturing techniques to decrease the manufacturing costs of medical products, making them more affordable and getting them to more consumers more rapidly at a reduced carbon and environmental footprint.

The UL research emphasizes the increasing significance of combining process engineering, modeling and data science to generate a better understanding of processes at a molecular scale for the optimization of pharmaceutical manufacturing.

The study has been published in the world-leading general science journal Proceedings of the National Academy of Sciences (PNAS).

Professor Gavin Walker, Bernal Chair of Pharmaceutical Powder Engineering and project lead, explained that: “This contribution offers a ‘proof of concept’ to make it achievable to model specific co-crystals at a molecular scale within a continuous pharmaceutical manufacturing process.

“Molecular interactions can be altered to optimise drug properties and this process can be crucial to the performance of a dosage form which links to the preparation of the safe delivery of the content of the drug product for the ultimate benefits of patients and society.

“There is huge value in improving the productivity of the drug development process. This study expands on possibilities that exist for future development of progressing towards more supportive mechanisms in the pharmaceutical manufacturing space, improving processing and reducing time to market for new medicine,” he added.

The study was led by Professor Walker and funded through CONFIRM, the SFI Research Center for Smart Manufacturing and SSPC, the SFI Research Center for Pharmaceuticals, which are both based at UL, and European funding through the MSCA ‘Process’ Co-Fund.

Professor Walker said of the research: “It will aid the current pharmaceutical development processes of exhaustive empirical experimentation, in that time and cost can be reduced through this more controlled and targeted approach via Smart Manufacturing techniques.

“The paper represents a significant bridge by adapting mathematical modeling developed in the discrete manufacturing sector into effective techniques for improving continuous manufacturing within the pharma-biopharma sector.

“This is critical to achieve UN Sustainable Development grand challenges in good health and wellbeing, as well as ensuring healthy lives and promoting well-being for all at all ages, optimizing biopharma processing and reducing time to market for new medicines,” he added.

Speaking about the research output, SSPC Director, Professor Damien Thompson, said: “The paper represents a significant deployment of data-driven molecular modeling for improving continuous manufacturing within the pharma-biopharma sector. It is great to see such impact from collaborative work bridging two SFI research centers hosted at University of Limerick.”

Dr Niall Keely, CONFIRM Strategic Research Manager, added: “The research presented in this paper highlights the significant impact of combining multiple science and engineering disciplines to advance knowledge of processes at the benefits molecular level that ultimately can lead to at the industrial scale and improved business processes such as faster time-to-market of products.”


the study, ‘A molecularly enhanced proof of concept for targeting cocrystals at molecular scale in continuous pharmaceuticals cocrystallization’by Milad Asgarpour Khansary, Saeed Shirazian and Gavin Walker, is published in the journal Proceedings of the National Academy of Sciences. It is available here:

For further information, please contact:

Alan Owens

Communications Officer

University of Limerick

+353 87 908 6633

About University of Limerick:

The University of Limerick is a research-led, independent, internationally focused university with 17,500 students and 1,800 staff. It is a young, energetic and enterprising university with a proud record of innovation in education and excellence in research and scholarship.

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